A Functional Variant rs3093023 in CCR6 Is Associated With IgA Nephropathy by Regulating Th17 Cells in a North Han Chinese Population

A Functional Variant rs3093023 in CCR6 Is Associated With IgA Nephropathy by Regulating Th17 Cells in a North Han Chinese Population

C-C chemokine receptor 6 (CCR6) is a susceptibility gene of various immune-related diseases, which was suggested to be shared with immunoglobulin A nephropathy (IgAN). In this study, we aimed to identify the functional variants. First, we analyzed the associations of CCR6 common and rare variants de...

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Bibliographic Details
Main Authors: Yue-miao Zhang, Xing-zi Liu, Xu-jie Zhou, Li-jun Liu, Su-fang Shi, Ping Hou, Ji-cheng Lv, Hong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
IgA nephropathy
CCR6
Th17 cells
genetic association
functional annotation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.600598/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.600598/full

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