Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development

Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development

DNA gyrase is a member of the DNA topoisomerase protein family that catalyzes the conversion of different topological forms of DNA into one another. It is the sole enzyme that causes DNA to negatively supercoil. The enzyme is tetrameric with two GyrA (“A'') and two GyrB (“B'') su...

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Bibliografski detalji
Glavni autori: K. Rajakumari, K. Aravind, M. Balamugundhan, Manjunathan Jagadeesan, Ambiga Somasundaram, Parthiban Brindha Devi, Pasiyappazham Ramasamy
Format: Članak
Jezik:English
Izdano: Elsevier 2024-12-01
Serija:European Journal of Medicinal Chemistry Reports
Teme:
DNA gyrase
DNA replication
Quinolones
Coumarin
Drug discovery
Drug resistance
Online pristup:http://www.sciencedirect.com/science/article/pii/S2772417424001055

Internet

http://www.sciencedirect.com/science/article/pii/S2772417424001055

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