Natural Merosesquiterpenes Activate the DNA Damage Response via DNA Strand Break Formation and Trigger Apoptotic Cell Death in p53-Wild-Type and Mutant Colorectal Cancer

Natural Merosesquiterpenes Activate the DNA Damage Response via DNA Strand Break Formation and Trigger Apoptotic Cell Death in p53-Wild-Type and Mutant Colorectal Cancer

Colorectal cancer (CRC) is a frequently occurring malignant disease with still low survival rates, highlighting the need for novel therapeutics. Merosesquiterpenes are secondary metabolites from marine sponges, which might be useful as antitumor agents. To address this issue, we made use of a compou...

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Bibliographic Details
Main Authors: Apisada Jiso, Philipp Demuth, Madeleine Bachowsky, Manuel Haas, Nina Seiwert, Daniel Heylmann, Birgit Rasenberger, Markus Christmann, Lea Dietrich, Thomas Brunner, Riyanti, Till F. Schäberle, Anuchit Plubrukarn, Jörg Fahrer
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
colorectal cancer
chemotherapy
tumor suppressor p53
apoptosis
natural compounds
DNA damage
Online Access:https://www.mdpi.com/2072-6694/13/13/3282

Internet

https://www.mdpi.com/2072-6694/13/13/3282

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