Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat

Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat

The liver—a central metabolic organ that integrates whole-body metabolism to maintain glucose and fatty-acid regulation, and detoxify ammonia—is susceptible to injuries induced by drugs and toxic substances. Although plasma metabolite profiles are increasingly investigated for their potential to det...

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Bibliographic Details
Main Authors: Kalyan C. Vinnakota, Venkat R. Pannala, Martha L. Wall, Mohsin Rahim, Shanea K. Estes, Irina Trenary, Tracy P. O’Brien, Richard L. Printz, Jaques Reifman, Masakazu Shiota, Jamey D. Young, Anders Wallqvist
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
metabolic network
rat
liver
plasma
metabolomics
fasting
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00161/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.00161/full

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