Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects

Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects

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Postoperative anatomical reconstruction and prevention of local recurrence after tumor resection are two vital clinical challenges in osteosarcoma treatment. A three-dimensional (3D)-printed porous Ti6Al4V scaffold (3DTi) is an ideal material for reconstructing critical bone defects with numerous ad...

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Bibliographic Details
Main Authors: Zehao Jing, Wanqiong Yuan, Jiedong Wang, Renhua Ni, Yu Qin, Zhinan Mao, Feng Wei, Chunli Song, Yufeng Zheng, Hong Cai, Zhongjun Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-03-01
Series:Bioactive Materials
Subjects:
3D-printed titanium alloy
Implant
Simvastatin
Osteosarcoma
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X2300350X

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http://www.sciencedirect.com/science/article/pii/S2452199X2300350X

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