Molecular transport through primary human small intestinal monolayers by culture on a collagen scaffold with a gradient of chemical cross-linking

Molecular transport through primary human small intestinal monolayers by culture on a collagen scaffold with a gradient of chemical cross-linking

Abstract Background The luminal surface of the small intestine is composed of a monolayer of cells overlying a lamina propria comprised of extracellular matrix (ECM) proteins. The ECM provides a porous substrate critical for nutrient exchange and cellular adhesion. The enterocytes within the epithel...

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Bibliographic Details
Main Authors: Jennifer E. Speer, Dulan B. Gunasekara, Yuli Wang, John K. Fallon, Peter J. Attayek, Philip C. Smith, Christopher E. Sims, Nancy L. Allbritton
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Journal of Biological Engineering
Subjects:
Intestinal transport
Stiffness
Extracellular matrix
Small intestine
Online Access:http://link.springer.com/article/10.1186/s13036-019-0165-4

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http://link.springer.com/article/10.1186/s13036-019-0165-4

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