Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium

Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium

It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of esophageal epithelial cells, contributing to...

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Bibliographic Details
Main Authors: Tomoaki Hishida, Eric Vazquez-Ferrer, Yuriko Hishida-Nozaki, Yuto Takemoto, Fumiyuki Hatanaka, Kei Yoshida, Javier Prieto, Sanjeeb Kumar Sahu, Yuta Takahashi, Pradeep Reddy, David D. O’Keefe, Concepcion Rodriguez Esteban, Paul S. Knoepfler, Estrella Nuñez Delicado, Antoni Castells, Josep M. Campistol, Ryuji Kato, Hiroshi Nakagawa, Juan Carlos Izpisua Belmonte
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
MYC
cancer
senescence
aging
mitochondria highlights
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.786031/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.786031/full

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