Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update

Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update

Citrate plays a central role in cancer cells’ metabolism and regulation. Derived from mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate lyase into acetyl-CoA and oxaloacetate. The rapid turnover of these molecules in proliferative cancer cells maintains a...

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Bibliographic Details
Main Authors: Philippe Icard, Antoine Coquerel, Zherui Wu, Joseph Gligorov, David Fuks, Ludovic Fournel, Hubert Lincet, Luca Simula
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
citrate
cancer cells
Warburg effect
ACLY
resistance to therapies
Online Access:https://www.mdpi.com/1422-0067/22/12/6587

Internet

https://www.mdpi.com/1422-0067/22/12/6587

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