A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids

A Trans-Ethnic Genome-Wide Association Study of Uterine Fibroids

Uterine fibroids affect up to 77% of women by menopause and account for up to $34 billion in healthcare costs each year. Although fibroid risk is heritable, genetic risk for fibroids is not well understood. We conducted a two-stage case-control meta-analysis of genetic variants in European and Afric...

Full description

Bibliographic Details
Main Authors: Todd L. Edwards, Ayush Giri, Jacklyn N. Hellwege, Katherine E. Hartmann, Elizabeth A. Stewart, Janina M. Jeff, Michael J. Bray, Sarah A. Pendergrass, Eric S. Torstenson, Jacob M. Keaton, Sarah H. Jones, Radhika P. Gogoi, Helena Kuivaniemi, Kathryn L. Jackson, Abel N. Kho, Iftikhar J. Kullo, Catherine A. McCarty, Hae Kyung Im, Jennifer A. Pacheco, Jyotishman Pathak, Marc S. Williams, Gerard Tromp, Eimear E. Kenny, Peggy L. Peissig, Joshua C. Denny, Dan M. Roden, Digna R. Velez Edwards
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Genetics
Subjects:
uterine fibroids
genome-wide association study (GWAS)
trans-ethnic
meta-analysis electronic health record (EHR)
genetically predicted gene expression (GPGE)
genetic architecture
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00511/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00511/full

Similar Items