L1CAM deployed perivascular tumor niche promotes vessel wall invasion of tumor thrombus and metastasis of renal cell carcinoma

Abstract The survival of tumor cells in the bloodstream, and vasculature adhesion at metastatic sites are crucial for tumor metastasis. Perivascular invasion aids tumor cell self-renewal, survival, and formation of metastases by facilitating readily available oxygen, nutrients, and endothelial-deriv...

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Bibliographic Details
Main Authors: Zonglong Wu, Yaqian Wu, Zhuo Liu, Yimeng Song, Liyuan Ge, Tan Du, Yunchong Liu, Li Liu, Cheng Liu, Lulin Ma
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01410-4