Over-Expressed GATA-1<sub>S</sub>, the Short Isoform of the Hematopoietic Transcriptional Factor GATA-1, Inhibits Ferroptosis in K562 Myeloid Leukemia Cells by Preventing Lipid Peroxidation

Over-Expressed GATA-1<sub>S</sub>, the Short Isoform of the Hematopoietic Transcriptional Factor GATA-1, Inhibits Ferroptosis in K562 Myeloid Leukemia Cells by Preventing Lipid Peroxidation

Ferroptosis is a recently recognized form of regulated cell death involving lipid peroxidation. Glutathione peroxidase 4 (GPX4) plays a central role in the regulation of ferroptosis through the suppression of lipid peroxidation generation. Connections have been reported between ferroptosis, lipid me...

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Bibliographic Details
Main Authors: Silvia Trombetti, Nunzia Iaccarino, Patrizia Riccio, Raffaele Sessa, Rosa Catapano, Marcella Salvatore, Stelina Luka, Sergio de Nicola, Paola Izzo, Sante Roperto, Pasqualino Maddalena, Antonio Randazzo, Michela Grosso
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antioxidants
Subjects:
ferroptosis
GATA-1 isoforms
glutathione peroxidase 4
myeloid leukemia
cell death
lipid peroxidation
Online Access:https://www.mdpi.com/2076-3921/12/3/537

Internet

https://www.mdpi.com/2076-3921/12/3/537

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