L- and T-type Ca2+ channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma

L- and T-type Ca2+ channels dichotomously contribute to retinal ganglion cell injury in experimental glaucoma

Retinal ganglion cell apoptotic death is the main pathological characteristic of glaucoma, which is the leading cause of irreversible blindness. Disruption of Ca2+ homeostasis plays an important role in glaucoma. Voltage-gated Ca2+ channel blockers have been shown to improve vision in patients with...

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Bibliographic Details
Main Authors: Hong-Ning Wang, Wen-Jing Qian, Guo-Li Zhao, Fang Li, Yan-Ying Miao, Bo Lei, Xing-Huai Sun, Zhong-Feng Wang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
apoptosis; cav1.2; cav3.3; chronic ocular hypertension; extracellular signal-regulated kinase; mitogen-activated protein kinase; nuclear factor-kappa b; patch-clamp; retina; tumor necrosis factor-α
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1570;epage=1577;aulast=Wang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=7;spage=1570;epage=1577;aulast=Wang

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