A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.

A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11.

Interleukin-11 (IL-11) is a pleiotropic cytokine approved by the FDA against chemotherapy-induced thrombocytopenia. From a combinatorial selection in a cancer patient, we isolated an IL-11-like peptide mapping to domain I of the IL-11 (sequence CGRRAGGSC). Although this motif has ligand attributes,...

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Bibliographic Details
Main Authors: Marina Cardó-Vila, Amado J Zurita, Ricardo J Giordano, Jessica Sun, Roberto Rangel, Liliana Guzman-Rojas, Cristiane D Anobom, Ana P Valente, Fábio C L Almeida, Johanna Lahdenranta, Mikhail G Kolonin, Wadih Arap, Renata Pasqualini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2565473?pdf=render

Internet

http://europepmc.org/articles/PMC2565473?pdf=render

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