Inhibition of ERO1a and IDO1 improves dendritic cell infiltration into pancreatic ductal adenocarcinoma

Inhibition of ERO1a and IDO1 improves dendritic cell infiltration into pancreatic ductal adenocarcinoma

IntroductionPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal and treatment resistant cancers. Due to its desmoplastic and hypoxic nature along with an abundance of myeloid cell infiltration and scarce T cell infiltration, PDAC is considered a cold tumor.MethodsHere we sought to inve...

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Bibliographic Details
Main Authors: Apple Hui Min Tay, Riccardo Cinotti, Newman Sui Kwan Sze, Andreas Lundqvist
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
ERO1a
IDO1
dendritic cell
PDAC
secretome
spheroid
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1264012/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1264012/full

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