Mutated CYP17A1 promotes atherosclerosis and early-onset coronary artery disease

Mutated CYP17A1 promotes atherosclerosis and early-onset coronary artery disease

Abstract Background Coronary artery disease (CAD) is a multi-factor complex trait and is heritable, especially in early-onset families. However, the genetic factors affecting the susceptibility of early-onset CAD are not fully characterized. Methods In the present study, we identified a rare nonsens...

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Bibliographic Details
Main Authors: Ting-Ting Wu, Ying-Ying Zheng, Xiang Ma, Wen-Juan Xiu, Hai-Tao Yang, Xian-Geng Hou, Yi Yang, You Chen, Yi-Tong Ma, Xiang Xie
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cell Communication and Signaling
Subjects:
Early-onset coronary artery disease
CYP17A1
Pathophysiology
Atherosclerosis
Online Access:https://doi.org/10.1186/s12964-023-01061-z

Internet

https://doi.org/10.1186/s12964-023-01061-z

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