A rabies virus-vectored vaccine expressing two copies of the Marburg virus glycoprotein gene induced neutralizing antibodies against Marburg virus in humanized mice

A rabies virus-vectored vaccine expressing two copies of the Marburg virus glycoprotein gene induced neutralizing antibodies against Marburg virus in humanized mice

ABSTRACTMarburg virus disease (MVD) is a lethal viral haemorrhagic fever caused by Marburg virus (MARV) with a case fatality rate as high as 88%. There is currently no vaccine or antiviral therapy approved for MVD. Due to high variation among MARV isolates, vaccines developed against one strain fail...

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Bibliographic Details
Main Authors: Jinhao Bi, Haojie Wang, Qiuxue Han, Hongyan Pei, Hualei Wang, Hongli Jin, Song Jin, Hang Chi, Songtao Yang, Yongkun Zhao, Feihu Yan, Liangpeng Ge, Xianzhu Xia
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
Marburg virus disease
Marburg virus
neutralizing antibodies
fully humanized antibody
transgenic mice
CAMouse
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2022.2149351

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https://www.tandfonline.com/doi/10.1080/22221751.2022.2149351

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