Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability.

Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability.

The Y-box binding protein-1 (YB-1) is an oncogenic transcription/translation factor that is activated by phosphorylation at S102 whereby it induces the expression of growth promoting genes such as EGFR and HER-2. We recently illustrated by an in vitro kinase assay that a novel peptide to YB-1 was hi...

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Bibliographic Details
Main Authors: Jennifer H Law, Yvonne Li, Karen To, Michelle Wang, Arezoo Astanehe, Karen Lambie, Jaspreet Dhillon, Steven J M Jones, Martin E Gleave, Connie J Eaves, Sandra E Dunn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20844753/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20844753/?tool=EBI

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