Discovery of a New CaMKII-Targeted Synthetic Lethal Therapy against Glioblastoma Stem-like Cells

Discovery of a New CaMKII-Targeted Synthetic Lethal Therapy against Glioblastoma Stem-like Cells

Glioblastoma stem-like cells (GSCs) drive tumor initiation, cancer invasion, immune evasion, and therapeutic resistance and are thus a key therapeutic target for improving treatment for glioblastoma multiforme (GBM). We previously identified calcium/calmodulin-dependent protein kinase II (CaMKII) as...

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Bibliographic Details
Main Authors: Jang Mi Han, Yu Jin Kim, Hye Jin Jung
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
synthetic lethal therapy
glioblastoma stem-like cells
calcium/calmodulin-dependent protein kinases II
neurokinin 1 receptor
hydrazinobenzoylcurcumin
berbamine
Online Access:https://www.mdpi.com/2072-6694/14/5/1315

Internet

https://www.mdpi.com/2072-6694/14/5/1315

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