Neurochemical Effects of 4-(2Chloro-4-Fluorobenzyl)-3-(2-Thienyl)-1,2,4-Oxadiazol-5(4H)-One in the Pentylenetetrazole (PTZ)-Induced Epileptic Seizure Zebrafish Model

Neurochemical Effects of 4-(2Chloro-4-Fluorobenzyl)-3-(2-Thienyl)-1,2,4-Oxadiazol-5(4H)-One in the Pentylenetetrazole (PTZ)-Induced Epileptic Seizure Zebrafish Model

Epilepsy is one of the most common neurological disorders, and it is characterized by spontaneous seizures. In a previous study, we identified 4-(2-chloro-4-fluorobenzyl)-3-(2-thienyl)-1,2,4-oxadiazol-5(4H)-one (GM-90432) as a novel anti-epileptic agent in chemically- or genetically-induced epilepti...

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Bibliographic Details
Main Authors: Seong Soon Kim, Hyemin Kan, Kyu-Seok Hwang, Jung Yoon Yang, Yuji Son, Dae-Seop Shin, Byung Hoi Lee, Se Hwan Ahn, Jin Hee Ahn, Sung-Hee Cho, Myung Ae Bae
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
epilepsy
neurotransmitter
neurosteroid
metabolic alteration
zebrafish
Online Access:https://www.mdpi.com/1422-0067/22/3/1285

Internet

https://www.mdpi.com/1422-0067/22/3/1285

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