Posttransplant Intramuscular Injection of PLX-R18 Mesenchymal-Like Adherent Stromal Cells Improves Human Hematopoietic Engraftment in A Murine Transplant Model

Posttransplant Intramuscular Injection of PLX-R18 Mesenchymal-Like Adherent Stromal Cells Improves Human Hematopoietic Engraftment in A Murine Transplant Model

Late-term complications of hematopoietic cell transplantation (HCT) are numerous and include incomplete engraftment. One possible mechanism of incomplete engraftment after HCT is cytokine-mediated suppression or dysfunction of the bone marrow microenvironment. Mesenchymal stromal cells (MSCs) elabor...

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Bibliographic Details
Main Authors: Leland Metheny, Saada Eid, Karen Lingas, Racheli Ofir, Lena Pinzur, Howard Meyerson, Hillard M. Lazarus, Alex Y. Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Medicine
Subjects:
cord blood stem cell transplantation
mesenchymal stromal cells
hematopoietic stem cell transplantation
engraftment
posttransplant complications
Online Access:http://journal.frontiersin.org/article/10.3389/fmed.2018.00037/full

Internet

http://journal.frontiersin.org/article/10.3389/fmed.2018.00037/full

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