MicroRNA-92b augments sorafenib resistance in hepatocellular carcinoma via targeting PTEN to activate PI3K/AKT/mTOR signaling

MicroRNA-92b augments sorafenib resistance in hepatocellular carcinoma via targeting PTEN to activate PI3K/AKT/mTOR signaling

Sorafenib (SOR) resistance is still a significant challenge for the effective treatment of hepatocellular carcinoma (HCC). The mechanism of sorafenib resistance remains unclear. Several microRNAs (miRNAs) have been identified as playing a role in impairing the sensitivity of tumor cells to treatment...

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Bibliographic Details
Main Authors: Zhouyang Cheng, Qingfeng Ni, Lei Qin, Yang Shi
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2021-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
MicroRNA-92b
Sorafenib
Resistance
PTEN
Hepatocellular carcinoma
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000900604&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021000900604&tlng=en

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