Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway

Cynaroside ameliorates TNBS-induced colitis by inhibiting intestinal epithelial cell apoptosis via the PI3K/AKT signalling pathway

Background and aimsPatients with Crohn’s disease (CD) exhibit excessive apoptosis of intestinal epithelial cells (IECs), which contributes to damage to the intestinal barrier structure and function, thereby playing a role in the progression of colitis. Preventing IEC apoptosis and protecting the int...

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Bibliographic Details
Main Authors: Ju Huang, Jing Li, Zhijun Geng, Lixia Yin, Minzhu Niu, Qingqing Li, Xinyue Liu, Xinke Cheng, Xiaofeng Zhang, Xue Song, Yueyue Wang, Lian Wang, Lugen Zuo, Jianguo Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
Crohn’s disease
cynaroside
IECs apoptosis
colonic organoids
PI3K/AKT
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1496068/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1496068/full

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