Spatial multiplexed immunofluorescence analysis reveals coordinated cellular networks associated with overall survival in metastatic osteosarcoma

Abstract Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have abysmal five-year overall survival rates. The complexity of the osteosarcoma immune tumor microenvironment has been implicated in clinical trial failures of various immunotherapies. The purpose of this...

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Bibliographic Details
Main Authors: Ryan A. Lacinski, Sebastian A. Dziadowicz, Vincent K. Melemai, Brody Fitzpatrick, John J. Pisquiy, Tanya Heim, Ines Lohse, Karen E. Schoedel, Nicolas J. Llosa, Kurt R. Weiss, Brock A. Lindsey
Format: Article
Language:English
Published: Nature Publishing Group 2024-09-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-024-00359-z