Neurometabolic Dysfunction in SPG11 Hereditary Spastic Paraplegia

Neurometabolic Dysfunction in SPG11 Hereditary Spastic Paraplegia

Background: Pathogenic variants in SPG11 cause the most common autosomal recessive complicated hereditary spastic paraplegia. Besides the prototypical combination of spastic paraplegia with a thin corpus callosum, obesity has increasingly been reported in this multisystem neurodegenerative disease....

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Bibliographic Details
Main Authors: Martin Regensburger, Laura Krumm, Manuel Alexander Schmidt, Andreas Schmid, Imke Tabea Spatz, Dominique Cornelius Marterstock, Christoph Kopp, Zacharias Kohl, Arnd Doerfler, Thomas Karrasch, Beate Winner, Jürgen Winkler
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Nutrients
Subjects:
SPG11
obesity
bioimpedance spectroscopy
leptin
adipokines
hypothalamus
Online Access:https://www.mdpi.com/2072-6643/14/22/4803

Internet

https://www.mdpi.com/2072-6643/14/22/4803

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