Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation

We previously showed that NUDT21-spanning copy-number variations (CNVs) are associated with intellectual disability (Gennarino et al., 2015). However, the patients’ CNVs also included other genes. To determine if reduced NUDT21 function alone can cause disease, we generated Nudt21+/- mice to mimic N...

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Bibliographic Details
Main Authors: Callison E Alcott, Hari Krishna Yalamanchili, Ping Ji, Meike E van der Heijden, Alexander Saltzman, Nathan Elrod, Ai Lin, Mei Leng, Bhoomi Bhatt, Shuang Hao, Qi Wang, Afaf Saliba, Jianrong Tang, Anna Malovannaya, Eric J Wagner, Zhandong Liu, Huda Y Zoghbi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
learning deficits
NUDT21
CFIm25
alternative polyadenylation
gene regulation
intellectual disability
Online Access:https://elifesciences.org/articles/50895

Internet

https://elifesciences.org/articles/50895

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