Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies

α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino acids encoded by the <i>SNCA</i> gene. Missense mutations and gene duplications in the <i>SNCA</i> gene cause hereditary Parkinson’s disease. Highly phosphorylated and abnormally aggregated...

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Bibliographic Details
Main Authors: Ichiro Kawahata, David I. Finkelstein, Kohji Fukunaga
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein
phosphorylation
Parkinson’s disease
dementia with Lewy bodies
multiple system atrophy
α-synucleinopathy
Online Access:https://www.mdpi.com/1422-0067/23/11/6216

Internet

https://www.mdpi.com/1422-0067/23/11/6216

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