The Impact of Acute Ingestion of a Ketone Monoester Drink on LPS-Stimulated NLRP3 Activation in Humans with Obesity

The Impact of Acute Ingestion of a Ketone Monoester Drink on LPS-Stimulated NLRP3 Activation in Humans with Obesity

Activation of the NOD-like receptor pyrin-domain containing 3 (NLRP3) inflammasome is associated with chronic low-grade inflammation in metabolic diseases such as obesity. Mechanistic studies have shown that β-hydroxybutyrate (OHB) attenuates activation of NLRP3, but human data are limited....

Full description

Bibliographic Details
Main Authors: Helena Neudorf, Étienne Myette-Côté, Jonathan P. Little
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Nutrients
Subjects:
ketones
obesity
immunometabolism
inflammation
caspase-1
inflammasome
beta-hydroxybutyrate
3-hydroxybutyric acid
interleukin-1β
nlr family
pyrin domain containing-3 protein
Online Access:https://www.mdpi.com/2072-6643/12/3/854

Internet

https://www.mdpi.com/2072-6643/12/3/854

Similar Items