In vitro IL-15-activated human naïve CD8+ T cells down-modulate the CD8β chain and become CD8αα T cells

In vitro IL-15-activated human naïve CD8+ T cells down-modulate the CD8β chain and become CD8αα T cells

Antigen-driven human effector-memory CD8+ T cells expressing low levels of the CD8β chain have been previously described. However, little is known on a possible antigen-independent trigger. We have examined the impact that IL-15 has on the expression of CD8β on purified human naïve CD8+ T cells afte...

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Bibliographic Details
Main Authors: André J. Esgalhado, Débora Reste-Ferreira, Sandra Weinhold, Markus Uhrberg, Elsa M. Cardoso, Fernando A. Arosa
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Immunology
Subjects:
IL-15
naïve CD8+ T cells
effector-memory CD8+ T cells
CD8β chain
downregulation
CD8α chain
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1252439/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1252439/full

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