CpG-Recoding in Zika Virus Genome Causes Host-Age-Dependent Attenuation of Infection With Protection Against Lethal Heterologous Challenge in Mice

CpG-Recoding in Zika Virus Genome Causes Host-Age-Dependent Attenuation of Infection With Protection Against Lethal Heterologous Challenge in Mice

Experimental increase of CpG dinucleotides in an RNA virus genome impairs infection providing a promising approach for vaccine development. While CpG recoding is an emerging and promising vaccine approach, little is known about infection phenotypes caused by recoded viruses in vivo. For example, inf...

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Bibliographic Details
Main Authors: Ivan Trus, Daniel Udenze, Nathalie Berube, Colette Wheler, Marie-Jocelyne Martel, Volker Gerdts, Uladzimir Karniychuk
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
CpG dinucleotide
Zika virus
neonate
adult
age
vaccine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03077/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03077/full

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