High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

Summary: Reoccurring/high-risk neuroblastoma (NB) tumors have the enrichment of non-RAS/RAF mutations along the mitogen-activated protein kinase (MAPK) signaling pathway, suggesting that activation of MEK/ERK is critical for their survival. However, based on preclinical data, MEK inhibitors are unli...

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Bibliographic Details
Main Authors: Jinyang Cai, Sheeba Jacob, Richard Kurupi, Krista M. Dalton, Colin Coon, Patricia Greninger, Regina K. Egan, Giovanna T. Stein, Ellen Murchie, Joseph McClanaghan, Yuta Adachi, Kentaro Hirade, Mikhail Dozmorov, John Glod, Sosipatros A. Boikos, Hiromichi Ebi, Huaixiang Hao, Giordano Caponigro, Cyril H. Benes, Anthony C. Faber
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472200897X

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http://www.sciencedirect.com/science/article/pii/S221112472200897X

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