Silencing of the TRIM58 Gene by Aberrant Promoter Methylation is Associated with a Poor Patient Outcome and Promotes Cell Proliferation and Migration in Clear Cell Renal Cell Carcinoma

Silencing of the TRIM58 Gene by Aberrant Promoter Methylation is Associated with a Poor Patient Outcome and Promotes Cell Proliferation and Migration in Clear Cell Renal Cell Carcinoma

To investigate the underlying molecular mechanism of tripartite motif-containing 58 (TRIM58) in the development of clear cell renal cell carcinoma (ccRCC), we explored TRIM58 expression and methylation in tumor tissues and the association with clinicopathological features and prognosis of tissue sam...

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Bibliographic Details
Main Authors: Ying Gan, Congcong Cao, Aolin Li, Haifeng Song, Guanyu Kuang, Binglei Ma, Quan Zhang, Qian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
clear cell renal cell carcinoma
TRIM58
DNA methylation
engineered demethyltransferase
CRISPR-dCas9
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.655126/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.655126/full

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