Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice

Abstract Amyloid-β (Aβ) deposition is one of the hallmarks of the amyloid hypothesis in Alzheimer’s disease (AD). Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease. The extent to which the data from mice can be transferr...

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Bibliographic Details
Main Authors: Johannes Steffen, Markus Krohn, Christina Schwitlick, Thomas Brüning, Kristin Paarmann, Claus U. Pietrzik, Henrik Biverstål, Baiba Jansone, Oliver Langer, Jens Pahnke
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Acta Neuropathologica Communications
Subjects:
Murine amyloid-beta
Abeta
Transgenic mice
Amyloid precursor protein
Alzheimer’s disease
Amyloidosis
Online Access:http://link.springer.com/article/10.1186/s40478-017-0448-2

Internet

http://link.springer.com/article/10.1186/s40478-017-0448-2

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