Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells

Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells

Pluripotency transcription programs by core transcription factors (CTFs) might be reset during M/G1 transition to maintain the pluripotency of embryonic stem cells (ESCs). However, little is known about how CTFs are governed during cell cycle progression. Here, we demonstrate that the regulation of...

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Bibliographic Details
Main Authors: Jihoon Shin, Tae Wan Kim, Hyunsoo Kim, Hye Ji Kim, Min Young Suh, Sangho Lee, Han-Teo Lee, Sojung Kwak, Sang-Eun Lee, Jong-Hyuk Lee, Hyonchol Jang, Eun-Jung Cho, Hong-Duk Youn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
aurkb
cell cycle of ESCs
oct4 phosphorylation
oct4 resetting
PP1
Online Access:https://elifesciences.org/articles/10877

Internet

https://elifesciences.org/articles/10877

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