Anti-nociceptive effects of low dose ketamine in mice may be mediated by the serotonergic systems

OBJECTIVE: In pain management, alternative medications are necessary due to the development of tolerance to traditional opioid analgesics. Literature data suggest that N-methyl-D-aspartate (NMDA) receptor antagonizing drugs can induce antinociception, and can reduce the opioid requirement. Ketamine...

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Bibliographic Details
Main Authors: Meral Erdinc, Emre Uyar, Ilker Kelle, Hasan Akkoc
Format: Article
Language:English
Published: AVES 2019-07-01
Series:Psychiatry and Clinical Psychopharmacology
Subjects:
Online Access:http://dx.doi.org/10.1080/24750573.2019.1605665