The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion.

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion.

Mitochondria mediate dual metabolic and Ca(2+) shuttling activities. While the former is required for Ca(2+) signalling linked to insulin secretion, the role of the latter in β cell function has not been well understood, primarily because the molecular identity of the mitochondrial Ca(2+) transporte...

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Bibliographic Details
Main Authors: Iulia I Nita, Michal Hershfinkel, Daniel Fishman, Eyal Ozeri, Guy A Rutter, Stefano L Sensi, Daniel Khananshvili, Eli C Lewis, Israel Sekler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3466326?pdf=render

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http://europepmc.org/articles/PMC3466326?pdf=render

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