SPATA2 and CYLD inhibit T cell infiltration into colorectal cancer via regulation of IFN-γ/STAT1 axis

SPATA2 and CYLD inhibit T cell infiltration into colorectal cancer via regulation of IFN-γ/STAT1 axis

IntroductionColorectal cancer (CRC) is largely refractory to currently available immunotherapies such as blockade of programmed cell death protein-1 (PD-1).ResultsIn this study, we identified SPATA2 and its protein partner CYLD as novel regulators of CXC-ligand 10 (CXCL10), a T-cell-attractant chemo...

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Bibliographic Details
Main Authors: Tze Guan Tan, Yulia Zybina, Cooper McKenna, Aleksandra Olow, Subhadra Jayaraman Rukmini, Michael Thomas Wong, Svetlana Sadekova, Alissa Chackerian, David Bauché
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
colon cancer
SPATA2
CYLD
STAT1
chemokines
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1016307/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1016307/full

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