Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma

Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma

Anaplastic Large Cell Lymphoma (ALCL) is a subtype of non-Hodgkin lymphoma frequently driven by the chimeric tyrosine kinase NPM-ALK, generated by the t (2,5)(p23;q35) translocation. While ALK+ ALCL belongs to mature T cell lymphomas, loss of T cell identity is observed in the majority of ALCL secon...

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Bibliographic Details
Main Authors: Giulia Mura, Elif Karaca Atabay, Matteo Menotti, Cinzia Martinengo, Chiara Ambrogio, Gloria Giacomello, Maddalena Arigoni, Martina Olivero, Raffaele A. Calogero, Roberto Chiarle, Claudia Voena
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
anaplastic large cell lymphoma
ALK
CD45
phosphatases
resistance
tyrosine kinase inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1085672/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1085672/full

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