Novel Bis-Ammonium Salts of Pyridoxine: Synthesis and Antimicrobial Properties

Novel Bis-Ammonium Salts of Pyridoxine: Synthesis and Antimicrobial Properties

A series of 108 novel quaternary bis-ammonium pyridoxine derivatives carrying various substituents at the quaternary nitrogen’s and acetal carbon was synthesized. Thirteen compounds exhibited antibacterial and antifungal activity (minimum inhibitory concentration (MIC) 0.25–16 µg/mL) comparable or s...

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Bibliographic Details
Main Authors: Nikita V. Shtyrlin, Mikhail V. Pugachev, Sergey V. Sapozhnikov, Marsel R. Garipov, Rusalia M. Vafina, Denis Y. Grishaev, Roman S. Pavelyev, Renata R. Kazakova, Mariya N. Agafonova, Alfiya G. Iksanova, Svetlana A. Lisovskaya, Marina I. Zeldi, Elena S. Krylova, Elena V. Nikitina, Alina E. Sabirova, Airat R. Kayumov, Yurii G. Shtyrlin
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
quaternary ammonium salts
pyridoxine
antibacterial activity
antifungal activity
cytotoxicity
biofilms
Online Access:https://www.mdpi.com/1420-3049/25/18/4341

Internet

https://www.mdpi.com/1420-3049/25/18/4341

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