Gut Microbiota Dysbiosis after Traumatic Brain Injury Contributes to Persistent Microglial Activation Associated with Upregulated Lyz2 and Shifted Tryptophan Metabolic Phenotype

Gut Microbiota Dysbiosis after Traumatic Brain Injury Contributes to Persistent Microglial Activation Associated with Upregulated Lyz2 and Shifted Tryptophan Metabolic Phenotype

Traumatic brain injury (TBI) is a common cause of disability and mortality, affecting millions of people every year. The neuroinflammation and immune response post-TBI initially have neuroprotective and reparative effects, but prolonged neuroinflammation leads to secondary injury and increases the r...

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Bibliographic Details
Main Authors: Zhipeng Zheng, Shuai Wang, Chenghao Wu, Yang Cao, Qiao Gu, Ying Zhu, Wei Zhang, Wei Hu
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Nutrients
Subjects:
gut microbiota
tryptophan metabolism
microglia
Lyz2
chronic neuroinflammation
traumatic brain injury
Online Access:https://www.mdpi.com/2072-6643/14/17/3467

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https://www.mdpi.com/2072-6643/14/17/3467

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