Prophylactic Sublingual Immunization with Mycobacterium tuberculosis Subunit Vaccine Incorporating the Natural Killer T Cell Agonist Alpha-Galactosylceramide Enhances Protective Immunity to Limit Pulmonary and Extra-Pulmonary Bacterial Burden in Mice

Prophylactic Sublingual Immunization with Mycobacterium tuberculosis Subunit Vaccine Incorporating the Natural Killer T Cell Agonist Alpha-Galactosylceramide Enhances Protective Immunity to Limit Pulmonary and Extra-Pulmonary Bacterial Burden in Mice

Infection by Mycobacterium tuberculosis (Mtb) remains a major global concern and the available Bacillus Calmette-Guerin (BCG) vaccine is poorly efficacious in adults. Therefore, alternative vaccines and delivery strategies focusing on Mtb antigens and appropriate immune stimulating adjuvants are nee...

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Bibliographic Details
Main Authors: Arshad Khan, Shailbala Singh, Gloria Galvan, Chinnaswamy Jagannath, K. Jagannadha Sastry
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Vaccines
Subjects:
tuberculosis vaccine
mucosal immunity
sublingual vaccination
natural killer T cells
alpha-galactosylceramide
subunit vaccine
antigen 85B and ESAT-6
TH1 immune responses
Online Access:https://www.mdpi.com/2076-393X/5/4/47

Internet

https://www.mdpi.com/2076-393X/5/4/47

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