Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy

Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy

Autosomal dominant optic atrophy (DOA) is a progressive form of blindness caused by degeneration of retinal ganglion cells and their axons, mainly caused by mutations in the OPA1 mitochondrial dynamin like GTPase (OPA1) gene. OPA1 encodes a dynamin-like GTPase present in the mitochondrial inner memb...

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Bibliographic Details
Main Authors: Yohei Nitta, Jiro Osaka, Ryuto Maki, Satoko Hakeda-Suzuki, Emiko Suzuki, Satoshi Ueki, Takashi Suzuki, Atsushi Sugie
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-08-01
Series:eLife
Subjects:
dominant optic atrophy
Drosophila
OPA1
axonal degeneration
Online Access:https://elifesciences.org/articles/87880

Internet

https://elifesciences.org/articles/87880

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