Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages

Dental pulp mesenchymal stem cell (DPSCs)-derived soluble factors, produced under hypoxic conditions, support angiogenesis via endothelial cell activation and generation of M2-like macrophages

Abstract Background Cell therapy has emerged as a revolutionary tool to repair damaged tissues by restoration of an adequate vasculature. Dental Pulp stem cells (DPSC), due to their easy biological access, ex vivo properties, and ability to support angiogenesis have been largely explored in regenera...

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Bibliographic Details
Main Authors: Ludovica Barone, Martina Cucchiara, Maria Teresa Palano, Barbara Bassani, Matteo Gallazzi, Federica Rossi, Mario Raspanti, Piero Antonio Zecca, Gianluca De Antoni, Christina Pagiatakis, Roberto Papait, Giovanni Bernardini, Antonino Bruno, Rosalba Gornati
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Biomedical Science
Subjects:
Dental pulp stem cells
Mesenchymal stem cells
Angiogenesis
Secretome
Tissue engineering
Macrophage polarization
Online Access:https://doi.org/10.1186/s12929-024-01087-6

Internet

https://doi.org/10.1186/s12929-024-01087-6

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