Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

The molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants.

Bibliographic Details
Main Authors: Minqing Jiang, Lei Liu, Xuelian He, Haibo Wang, Wensheng Lin, Huimin Wang, Sung O. Yoon, Teresa L. Wood, Q. Richard Lu
Format: Article
Language:English
Published: Nature Portfolio 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12185

Internet

https://doi.org/10.1038/ncomms12185

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