Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes
The molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12185 |
| _version_ | 1818842107267252224 |
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| author | Minqing Jiang Lei Liu Xuelian He Haibo Wang Wensheng Lin Huimin Wang Sung O. Yoon Teresa L. Wood Q. Richard Lu |
| author_facet | Minqing Jiang Lei Liu Xuelian He Haibo Wang Wensheng Lin Huimin Wang Sung O. Yoon Teresa L. Wood Q. Richard Lu |
| author_sort | Minqing Jiang |
| collection | DOAJ |
| description | The molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants. |
| first_indexed | 2024-12-19T04:36:43Z |
| format | Article |
| id | doaj.art-3183cd29a5be4f2ab4d6cef95ce98db7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:36:43Z |
| publishDate | 2016-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3183cd29a5be4f2ab4d6cef95ce98db72022-12-21T20:35:43ZengNature PortfolioNature Communications2041-17232016-07-017111510.1038/ncomms12185Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytesMinqing Jiang0Lei Liu1Xuelian He2Haibo Wang3Wensheng Lin4Huimin Wang5Sung O. Yoon6Teresa L. Wood7Q. Richard Lu8Key Laboratory of Brain Functional Genomics of STCSM, Institute of Cognitive Neuroscience, East China Normal UniversityDepartment of Pediatrics, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Second Hospital, Sichuan UniversityDepartment of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, University of CincinnatiDepartment of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, University of CincinnatiDepartment of Neuroscience, Institute for Translational Neuroscience, University of MinnesotaKey Laboratory of Brain Functional Genomics of STCSM, Institute of Cognitive Neuroscience, East China Normal UniversityDepartment of Molecular and Cellular Biochemistry, Center for Molecular Neurobiology, The Ohio State UniversityDepartment of Neurology and Neuroscience, New Jersey Medical School Cancer Center, Rutgers Biomedical and Health SciencesDepartment of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, University of CincinnatiThe molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants.https://doi.org/10.1038/ncomms12185 |
| spellingShingle | Minqing Jiang Lei Liu Xuelian He Haibo Wang Wensheng Lin Huimin Wang Sung O. Yoon Teresa L. Wood Q. Richard Lu Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes Nature Communications |
| title | Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes |
| title_full | Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes |
| title_fullStr | Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes |
| title_full_unstemmed | Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes |
| title_short | Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes |
| title_sort | regulation of perk eif2α signalling by tuberous sclerosis complex 1 controls homoeostasis and survival of myelinating oligodendrocytes |
| url | https://doi.org/10.1038/ncomms12185 |
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