Mechanism of Dissolution Enhancement and Bioavailability of Poorly Water Soluble Celecoxib by Preparing Stable Amorphous Nanoparticles

Purpose: Nanoparticle engineering offers promising methods for the formulation of poorly water soluble drug compounds. The aim of the present work was to enhance dissolution and oral bioavailability of poorly water-soluble celecoxib (CXB) by preparing stable CXB nanoparticles using a promising metho...

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Bibliographic Details
Main Authors: Yinghui Liu, Changshan Sun, Yanru Hao, Tongying Jiang, Li Zheng, Siling Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-12-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/9456