MicroRNA29B induces fetal hemoglobin via inhibition of the HBG repressor protein MYB in vitro and in humanized sickle cell mice

MicroRNA29B induces fetal hemoglobin via inhibition of the HBG repressor protein MYB in vitro and in humanized sickle cell mice

IntroductionTherapeutic strategies aimed at reactivating HBG gene transcription and fetal hemoglobin (HbF) synthesis remain the most effective strategy to ameliorate the clinical symptoms of sickle cell disease (SCD). We previously identified microRNA29B (MIR29B) as a novel HbF inducer via targeting...

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Bibliographic Details
Main Authors: Qingqing Gu, Chithra D. Palani, Alana Smith, Biaori Li, Ernestine Kubi Amos-Abanyie, Ugochi Ogu, Lu Lu, Betty S. Pace, Athena Starlard-Davenport
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Medicine
Subjects:
MIR29B
fetal hemoglobin (HbF)
MYB
HBG
sickle cell
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.1043686/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.1043686/full

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