New Application of <i>cyclo</i>Saligenyl Prodrugs Approach for the Delivery of Fosfoxacin Derivatives in Mycobacteria

New Application of <i>cyclo</i>Saligenyl Prodrugs Approach for the Delivery of Fosfoxacin Derivatives in Mycobacteria

In this work, we implemented for the first time the <i>cyclo</i>Saligenyl prodrug strategy to increase the bioavailability of fosmidomycin phosphate analogs in bacteria. Here, we report the synthesis of 34 <i>cyclo</i>Saligenyl prodrugs of fosfoxacin and its derivatives. Amon...

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Bibliographic Details
Main Authors: Mathilde Munier, Denis Tritsch, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
isoprenoid biosynthesis
<i>cyclo</i>Saligenyl prodrug
fosfoxacin
deoxyxylulose 5-phosphate reducto-isomerase
<i>Mycobacterium smegmatis</i>
Online Access:https://www.mdpi.com/1420-3049/28/23/7713

Internet

https://www.mdpi.com/1420-3049/28/23/7713

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