Effects of Creatine Supplementation on Brain Function and Health
While the vast majority of research involving creatine supplementation has focused on skeletal muscle, there is a small body of accumulating research that has focused on creatine and the brain. Preliminary studies indicate that creatine supplementation (and guanidinoacetic acid; GAA) has the ability...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/5/921 |
| _version_ | 1797474219607457792 |
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| author | Scott C. Forbes Dean M. Cordingley Stephen M. Cornish Bruno Gualano Hamilton Roschel Sergej M. Ostojic Eric S. Rawson Brian D. Roy Konstantinos Prokopidis Panagiotis Giannos Darren G. Candow |
| author_facet | Scott C. Forbes Dean M. Cordingley Stephen M. Cornish Bruno Gualano Hamilton Roschel Sergej M. Ostojic Eric S. Rawson Brian D. Roy Konstantinos Prokopidis Panagiotis Giannos Darren G. Candow |
| author_sort | Scott C. Forbes |
| collection | DOAJ |
| description | While the vast majority of research involving creatine supplementation has focused on skeletal muscle, there is a small body of accumulating research that has focused on creatine and the brain. Preliminary studies indicate that creatine supplementation (and guanidinoacetic acid; GAA) has the ability to increase brain creatine content in humans. Furthermore, creatine has shown some promise for attenuating symptoms of concussion, mild traumatic brain injury and depression but its effect on neurodegenerative diseases appears to be lacking. The purpose of this narrative review is to summarize the current body of research pertaining to creatine supplementation on total creatine and phophorylcreatine (PCr) content, explore GAA as an alternative or adjunct to creatine supplementation on brain creatine uptake, assess the impact of creatine on cognition with a focus on sleep deprivation, discuss the effects of creatine supplementation on a variety of neurological and mental health conditions, and outline recent advances on creatine supplementation as a neuroprotective supplement following traumatic brain injury or concussion. |
| first_indexed | 2024-03-09T20:27:01Z |
| format | Article |
| id | doaj.art-3191809520a0466ba844722e24e163e0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T20:27:01Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-3191809520a0466ba844722e24e163e02023-11-23T23:31:59ZengMDPI AGNutrients2072-66432022-02-0114592110.3390/nu14050921Effects of Creatine Supplementation on Brain Function and HealthScott C. Forbes0Dean M. Cordingley1Stephen M. Cornish2Bruno Gualano3Hamilton Roschel4Sergej M. Ostojic5Eric S. Rawson6Brian D. Roy7Konstantinos Prokopidis8Panagiotis Giannos9Darren G. Candow10Department of Physical Education Studies, Faculty of Education, Brandon University, Brandon, MB R7A 6A9, CanadaApplied Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaCentre for Aging, University of Manitoba, Winnipeg, MB R3T 2N2, CanadaApplied Physiology & Nutrition Research Group, Rheumatology Division, School of Physical Education and Sport, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, BrazilApplied Physiology & Nutrition Research Group, Rheumatology Division, School of Physical Education and Sport, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo 01246-903, BrazilDepartment of Nutrition and Public Health, University of Agder, 4604 Kristiansand, NorwayDepartment of Health, Nutrition, and Exercise Science, Messiah University, Mechanicsburg, PA 17055, USADepartment of Kinesiology, Brock University, St. Catharines, ON L2S 3A1, CanadaDepartment of Musculoskeletal Biology, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L73 FAK, UKDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, UKFaculty of Kinesiology and Health Studies, University of Regina, Regina, SK S4S 0A2, CanadaWhile the vast majority of research involving creatine supplementation has focused on skeletal muscle, there is a small body of accumulating research that has focused on creatine and the brain. Preliminary studies indicate that creatine supplementation (and guanidinoacetic acid; GAA) has the ability to increase brain creatine content in humans. Furthermore, creatine has shown some promise for attenuating symptoms of concussion, mild traumatic brain injury and depression but its effect on neurodegenerative diseases appears to be lacking. The purpose of this narrative review is to summarize the current body of research pertaining to creatine supplementation on total creatine and phophorylcreatine (PCr) content, explore GAA as an alternative or adjunct to creatine supplementation on brain creatine uptake, assess the impact of creatine on cognition with a focus on sleep deprivation, discuss the effects of creatine supplementation on a variety of neurological and mental health conditions, and outline recent advances on creatine supplementation as a neuroprotective supplement following traumatic brain injury or concussion.https://www.mdpi.com/2072-6643/14/5/921supplementationmental healthdepressionamino acids |
| spellingShingle | Scott C. Forbes Dean M. Cordingley Stephen M. Cornish Bruno Gualano Hamilton Roschel Sergej M. Ostojic Eric S. Rawson Brian D. Roy Konstantinos Prokopidis Panagiotis Giannos Darren G. Candow Effects of Creatine Supplementation on Brain Function and Health Nutrients supplementation mental health depression amino acids |
| title | Effects of Creatine Supplementation on Brain Function and Health |
| title_full | Effects of Creatine Supplementation on Brain Function and Health |
| title_fullStr | Effects of Creatine Supplementation on Brain Function and Health |
| title_full_unstemmed | Effects of Creatine Supplementation on Brain Function and Health |
| title_short | Effects of Creatine Supplementation on Brain Function and Health |
| title_sort | effects of creatine supplementation on brain function and health |
| topic | supplementation mental health depression amino acids |
| url | https://www.mdpi.com/2072-6643/14/5/921 |
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