A Metalloproteinase Cocktail from the Venom of <i>Protobothrops flavoviridis</i> Cleaves Amyloid Beta Peptides at the α-Cleavage Site

A Metalloproteinase Cocktail from the Venom of <i>Protobothrops flavoviridis</i> Cleaves Amyloid Beta Peptides at the α-Cleavage Site

A disintegrin and metalloproteinase (ADAM) family proteins are a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell surface protein ectodomains, including amyloid precursor protein (APP). Human ADAM 9, 10, and 17 proteolyze APPs and produce non-amy...

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Bibliographic Details
Main Authors: Eugene Futai, Hajime Kawasaki, Shinichi Sato, Khadija Daoudi, Masafumi Hidaka, Taisuke Tomita, Tomohisa Ogawa
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Toxins
Subjects:
α-secretase
a disintegrin and metalloproteinase (ADAM)
Alzheimer’s disease
amyloid beta (Aβ)
amyloid precursor protein (APP)
snake venom metalloproteinase (SVMP)
Online Access:https://www.mdpi.com/2072-6651/15/8/500

Internet

https://www.mdpi.com/2072-6651/15/8/500

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