Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

Summary: We report that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant replacement during the coronavirus disease 2019 (COVID-19) pandemic. Delta SARS-CoV-2 efficiently outcompetes the Alpha variant in human lung...

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Bibliographic Details
Main Authors: Yang Liu, Jianying Liu, Bryan A. Johnson, Hongjie Xia, Zhiqiang Ku, Craig Schindewolf, Steven G. Widen, Zhiqiang An, Scott C. Weaver, Vineet D. Menachery, Xuping Xie, Pei-Yong Shi
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Cell Reports
Subjects:
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722006003

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http://www.sciencedirect.com/science/article/pii/S2211124722006003

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